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The Text Book of Novel Drug Delivery Systems is a comprehensive guide that delves into the advanced methodologies and technologies used in the design and development of innovative drug delivery systems. It begins with a detailed exploration of controlled drug delivery systems, highlighting the principles of diffusion, dissolution, and ion exchange, and discussing the physicochemical and biological properties essential for effective formulation. The book then shifts focus to polymers, emphasizing their classifications, properties, and critical role in ensuring controlled and sustained drug release. Microencapsulation is explored in depth, including the types of microspheres, microcapsules, and techniques employed to achieve precise drug targeting and stability. The text also examines mucosal drug delivery systems, detailing mucoadhesion principles and formulation considerations, particularly for buccal routes. Readers will gain insights into implantable systems, including concepts of osmotic pumps and long-term implants. The section on transdermal systems offers an understanding of skin permeation, formulation components, and enhancement strategies. The book comprehensively covers gastroretentive systems, offering multiple approaches like floating and adhesive systems to prolong gastric residence time. The nasopulmonary delivery chapter outlines formulation strategies for inhalers, sprays, and nebulizers. An in-depth look at targeted delivery systems introduces liposomes, niosomes, nanoparticles, and monoclonal antibodies, explaining their applications in delivering drugs precisely to disease sites. Lastly, ocular and intrauterine delivery systems are discussed, with emphasis on overcoming biological barriers and designing effective formulations such as ocuserts and intrauterine devices (IUDs). This textbook is ideal for pharmacy students, researchers, and professionals seeking a foundational and applied understanding of modern drug delivery technologies.